Dr. Jean Zhao's lab is interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to study oncogenic alterations in kinases that are involved in tumor formation and metastasis. In addition to our unique genetically engineered mouse models, we have developed a number of additional experimental systems, including, synthetic human tumors, and kinome-wide libraries of activated kinases to elucidate the mechanisms by which kinases function in cancer.
July 17, 2015
The Zhao lab took two of the three top honors in the Poster Contest of this year’s Cancer Biology Retreat held at UMass Boston on Friday, July 17th. Dr. Jing Ni’s poster entitled “Orthotopic PDX models of HER2+ breast cancer brain metastases facilitates discovery of a selective targeted therapy yielding durable remissions” won the category “Most Promising Preliminary Result”. Dr. Yubao Wang’s poster entitled “CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer” took the prize for the “Best Mature Project”. Dr. Wang’s work has also resulted in a paper recently accepted for publication in Cell. Congratulations to Dr. Wang and Dr. Ni!
September 23, 2011Study Finds Key to Drug Resistance
Sophisticated "targeted" drug therapies are improving cancer care by selectively shutting down abnormal growth switches in tumor cells while avoiding toxicity to normal tissues. In some cases, though, tumors that are initially sensitive to these drugs first regress but then activate different, “backup” genetic signals that enable them to circumvent the therapy. A new discovery by Jean Zhao, PhD, and colleagues may help physicians predict which tumors are likely to become resistant to a given drug, and identify the secondary pathways they are activating to escape the original therapy... read the full story here
Yuzugullu et al. A PI3K p110beta-Rac signaling loop mediates Pten-loss-induced perturbation of hematopoiesis and leukemogenesis. Nature Communication. 2015, In Press
Wang et al., CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer. Cell. 2015, In Press