This is the Zhao lab.

Our laboratory is interested in understanding the diverse signaling pathways and networks regulating essential basic cellular processes in normal and cancer cells. We use a multi-pronged approach in which science and technology from molecular biology, chemical biology, genetics, systems biology, next-generation sequencing, nanotechnology, immunotherapy, and novel mouse models of human cancer converge. In this way, we not only gain a better understanding of the alterations involved in tumor initiation, progression, recurrence and metastasis, but we also identify novel targets and develop new therapeutic regimens...

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Recent Lab News

September 29, 2015

Dr. Yubao Wang's recently published Cell paper on CDK-7 is featured on the journal's Facebook page. Congratulations!

September 21, 2015

Shane O'Neal joins the Zhao Lab as a Research Technician. Welcome, Shane!

Dr. Sayuri Kitajima joins the Zhao Lab as a Research Fellow. Welcome, Sayuri!

September 8, 2015

Sheila Drakeley joins the Zhao Lab as an Undergraduate Student. Welcome, Sheila!

August 3, 2015

Amanda Zhou joins the Zhao Lab as a Research Trainee. Welcome, Amanda!

Kayley Abell-Hart joins the Zhao Lab as a Research Technician. Welcome, Kayley!

Jillian Lu joins the Zhao lab as a Summer Intern. Welcome, Jillian!

July 17, 2015

The Zhao lab took two of the three top honors in the Poster Contest of this year’s Cancer Biology Retreat: Dr. Jing Ni for the "Most Promising Preliminary Result" and Dr. Yubao Wang for the "Best Mature Project."

July 6, 2015

Emma Pan joins the Zhao Lab as a Research Trainee. Welcome, Emma!

May 28, 2015

Lauren Thorpe was honored in the 8th Annual DMS Hooding Ceremony with her fellow 2015 Graduating Class in the Division of Medical Sciences at the Harvard Medical School. Congratulations, Dr. Thorpe!

May 18, 2015

Dr. Liya Ding joins the Zhao lab as a Research Fellow. Welcome, Liya!

March 30, 2015

Dr. Yunneng Tang joins the Zhao lab as a Research Fellow. Welcome, Yunneng!

December 11, 2014

Lauren Thorpe successfully defended her PhD dissertation. Congratulations, Lauren!

May 17, 2012

Speeding Discovery from Lab to Clinic
Dana-Farber's Jean Zhao, PhD, has demonstrated that proteins known as PI3 kinases play a key role in these alternate circuits. Researchers have begun to explore whether drugs that target those kinases can offer a useful therapy for cancers with an activation of the PI3 kinase pathway.

September 23, 2011

Study Finds Key to Drug Resistance

A new discovery by Jean Zhao, PhD, and colleagues may help physicians predict which tumors are likely to become resistant to a given drug, and identify the secondary pathways they are activating to escape the original therapy.

Recent Publications

Yuzugullu et al. A PI3K p110beta-Rac signaling loop mediates Pten-loss-induced perturbation of hematopoiesis and leukemogenesis.  Nature Communication.
2015, In Press

Wang et al., CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer.   Cell.
September 2015

Vantler et al., Class IA Phosphatidylinositol 3-Kinase Isoform p110α Mediates Vascular Remodeling.   Arterioscler Thromb Vasc Biol.
June 2015

Tan et al., Light-triggered, self-immolative nucleic Acid-drug nanostructures.   J Am Chem Soc.
May 2015

Usman et al., Chemopreventive effects of aspirin at a glance.   Biochim Biophys Acta.
April 2015

Matheny et al., Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis.   Mol Cell Biol.
January 2015

Costa et al., Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.   Cancer Cell.
January 2015

Thorpe et al., PI3K in cancer: divergent roles of isoforms, modes of activation, and therapeutic targeting.   Nature Rev Cancer.
December 2014

Li et al., Cyclin C is a haploinsufficient tumour suppressor.   Nat Cell Biol.
November 2014

Wang et al., MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.   Elife.
May 2014

Schmit et al., PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.   Proc Natl Acad Sci USA.
April 2014

Gritsman et al., Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α.   J Clin Invest.
April 2014

Cheng et al., A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 is highly responsive to mTOR inhibition.   Cancer Res.
January 2014

See the complete list of Dr. Zhao's Publications