This is the Zhao lab.

Our laboratory is interested in understanding the diverse signaling pathways and networks regulating essential basic cellular processes in normal and cancer cells. We use a multi-pronged approach in which science and technology from molecular biology, chemical biology, genetics, systems biology, next-generation sequencing, nanotechnology, immunotherapy, and novel mouse models of human cancer converge. In this way, we not only gain a better understanding of the alterations involved in tumor initiation, progression, recurrence and metastasis, but we also identify novel targets and develop new therapeutic regimens...

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Recent Lab News

August 16, 2016

Dr. Johann Bergholz received a Postdoctoral Fellowship from the Susan G. Komen Foundation to support his research project entitled "Development of PI3Kß-based combination therapies in PTEN-deficient breast cancer". Congratulations, Dr. Bergholz!

July 2016

Dr. Ni's recent Nature Medicine article made it to the cover of their July edition. Congratulations! See the cover art in our "Publications" page or HERE! Artwork by Erin Dewalt and Susanne Ramm.

July 13, 2016

Felicia Tang joins the Zhao Lab as a Research Trainee. Welcome, Felicia!

July 12, 2016

Dr. Qiwei Wang joins the Zhao Lab as a Research Fellow. Welcome, Qiwei!

July 5, 2016

Emma Pan joins the Zhao Lab as a Research Trainee. Welcome, Emma!

June 30, 2016

Shane O'Neal is leaving the Zhao Lab for graduate studies at Duke University in the fall. Best wishes, Shane!

June 27, 2016

Dr. Tao Jiang joins the Zhao Lab as a Scientist. Welcome, Tao!

Amanda Zhou and Peter Wang join the Zhao Lab as Research Trainees. Welcome, Amanda and Peter!

June 20, 2016

Shandon Coffman joins the Zhao Lab as a Summer Student. Welcome, Michael!

June 6, 2016

Dr. Jing Ni's paper entitled "Combination inhibition of PI3K and mTORC1 yields durable remission in mice bearing orthotopic patient- derived xenografts of HER2-positive breast cancer brain metastases" has been e-published in Nature Medicine. Congratulations!

June 13, 2016

Michael Kearns joins the Zhao Lab as a Research Technician. Welcome, Michael!

February 22, 2016

Haley BrinJones joins the Zhao Lab as a Research Technician. Welcome, Haley!

February 9, 2016

Dr. Shom Goel's manuscript entitled Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors has been accepted for publication by Cancer Cell and will appear in the March issue of the journal. Congratulations!!

December 10, 2015

Dr. Hailing Chen's Oncogene paper makes it to the Top Story of the Week on Mammary Cell News!   Congratulations!!

November 30, 2015

Yanzhi Wang joins the Zhao Lab as a Research Technician. Welcome, Yanzhi!

October 28, 2015

Dr. Haluk Yuzugullu and his wife celebrated the birth of a beautiful baby girl! The family is doing well.

October 12, 2015

Dr. Haluk Yuzugullu's recently published paper in Nature Communication is rated "most read" for the week of 10/5/15 by ResearchGate. Congratulations!

October 8, 2015

Dr. Wang's Cell paper continues to be recognized. It is highlighted on Dana-Farber's web site. It is also featured in Science Signaling. Congratulations again!!

September 29, 2015

Dr. Yubao Wang's recently published Cell paper on CDK-7 is featured on the journal's Facebook page. Congratulations!

September 21, 2015

Shane O'Neal joins the Zhao Lab as a Research Technician. Welcome, Shane!

Dr. Sayuri Kitajima joins the Zhao Lab as a Research Fellow. Welcome, Sayuri!

September 8, 2015

Sheila Drakeley joins the Zhao Lab as an Undergraduate Student. Welcome, Sheila!

August 3, 2015

Amanda Zhou joins the Zhao Lab as a Research Trainee. Welcome, Amanda!

Kayley Abell-Hart joins the Zhao Lab as a Research Technician. Welcome, Kayley!

Jillian Lu joins the Zhao lab as a Summer Intern. Welcome, Jillian!

July 17, 2015

The Zhao lab took two of the three top honors in the Poster Contest of this year’s Cancer Biology Retreat: Dr. Jing Ni for the "Most Promising Preliminary Result" and Dr. Yubao Wang for the "Best Mature Project."

July 6, 2015

Emma Pan joins the Zhao Lab as a Research Trainee. Welcome, Emma!

May 28, 2015

Lauren Thorpe was honored in the 8th Annual DMS Hooding Ceremony with her fellow 2015 Graduating Class in the Division of Medical Sciences at the Harvard Medical School. Congratulations, Dr. Thorpe!

May 18, 2015

Dr. Liya Ding joins the Zhao lab as a Research Fellow. Welcome, Liya!

March 30, 2015

Dr. Yunneng Tang joins the Zhao lab as a Research Fellow. Welcome, Yunneng!

December 11, 2014

Lauren Thorpe successfully defended her PhD dissertation. Congratulations, Lauren!

Recent Publications

Wang et al. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival  Proc Natl Acad Sci USA.
July 2016

Ni et al. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases  Nature Medicine.
June 2016

Goel et al. Overcoming therapeutic resistance in HER2-positive breast cancers with CDK4/6 inhibitors  Cancer Cell.
March 2016

Cheng et al. PIK3CAH1047R- and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling.  Oncogene.
December 2015, advance online publication

Wang et al. PI3K-p110α mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers.  Oncogene.
October 2015

Yuzugullu et al. A PI3K p110beta-Rac signaling loop mediates Pten-loss-induced perturbation of hematopoiesis and leukemogenesis.  Nature Communication.
October 2015

Wang et al., CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer.   Cell.
September 2015

Vantler et al., Class IA Phosphatidylinositol 3-Kinase Isoform p110α Mediates Vascular Remodeling.   Arterioscler Thromb Vasc Biol.
June 2015

Tan et al., Light-triggered, self-immolative nucleic Acid-drug nanostructures.   J Am Chem Soc.
May 2015

Usman et al., Chemopreventive effects of aspirin at a glance.   Biochim Biophys Acta.
April 2015

Matheny et al., Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis.   Mol Cell Biol.
January 2015

Costa et al., Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.   Cancer Cell.
January 2015

Thorpe et al., PI3K in cancer: divergent roles of isoforms, modes of activation, and therapeutic targeting.   Nature Rev Cancer.
December 2014

Li et al., Cyclin C is a haploinsufficient tumour suppressor.   Nat Cell Biol.
November 2014

Wang et al., MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.   Elife.
May 2014

Schmit et al., PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.   Proc Natl Acad Sci USA.
April 2014

Gritsman et al., Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α.   J Clin Invest.
April 2014

Cheng et al., A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 is highly responsive to mTOR inhibition.   Cancer Res.
January 2014

See the complete list of Prof. Zhao's Publications